First-line systemic therapies for ovarian cancer
Sandro Pignata, MD, PhD
A 58-year-old pianist presented to her gynecologist with vague pelvic discomfort and abdominal bloating of 2 months duration. Pelvic examination shows right adnexal mass.
- Labs: CBC and biochemistry panels WNL, CA125 is elevated to 178 U/mL
- Radiology: Abdominal CT shows right adnexal mass 8 cm x 8 cm and small volume of ascites. Chest x-ray is normal
- Surgery: TAH, BSO, omentectomy and pelvic peritoneal debulking; no postoperative residuals
- Cytology: Reveals malignant ascites
- Pathology: Microscopic seeding of grade 3 serous cystadenocarcinoma in abdominal peritoneum is confirmed (stage IIIA)
- Clinical course: CA125 after surgery fell to 95 U/mL
- History: No comorbid illnesses or family history of ovarian and/or breast cancer
- ECOG performance status: 1
Participate:
Part I
Which of the following chemotherapy regimens would you recommend for initial systemic chemotherapy for this patient?
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SESSION II: Ovarian Cancer I: Surgery and First-Line Therapy
- State-of-the-art surgical strategies in ovarian cancer: How to do it?
Andreas du Bois, MD, PhD - Interactive clinical case:
First-line systemic therapies for ovarian cancer
Sandro Pignata, MD, PhD - Definition and characterization of low-grade and high-grade ovarian serous carcinomas
Ie-Ming Shih, MD, PhD
This activity is supported by Morphotek and MSD.
